Burden of Disease today:
10-year risk of cardiovascular events:1
- Diabetes.
- Previous personal history of CHD or non-coronary atherosclerosis (e.g., abdominal aortic aneurysm, peripheral artery disease, carotid artery stenosis).
- A family history of cardiovascular disease before age 50 in male relatives or age 60 in female relatives.
- Tobacco use.
- Hypertension.
- Obesity (BMI >30).
Cardiovascular disease, including coronary heart disease, accounts for nearly half of all deaths in the United States. Over the past 50 years, there has been a long-term downward trend in cardiovascular mortality associated with improved risk factor management and access to early detection and new treatments. The 2002 age-adjusted death rate for heart disease was 59% lower than the rate in 1950.2
The lifetime risk of having a coronary heart disease event, calculated at age 40, is estimated to be 49% for men and 32% for women in the United States; nearly one third of coronary heart disease events are attributable to total cholesterol levels above 200 mg/dL. Consistent, good-quality evidence from long-term prospective studies has shown that high levels of total cholesterol and LDL-C and low levels of HDL-C are important risk factors for coronary heart disease. The risk for coronary heart disease events and mortality increases with increasing levels of total cholesterol and LDL-C and declining levels of HDL-C, in a continuous and graded fashion, with no clear threshold. Coronary heart disease mortality is associated with several risk factors, including dyslipidemia, high blood pressure, tobacco use, diabetes, a family history of premature coronary heart disease, older age, male gender, and diet; other risk factors for coronary heart disease include socioeconomic status, obesity, and physical inactivity. Consideration of lipid levels along with other risk factors allows for an accurate estimation of coronary heart disease risk.3
References:
1.Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97:1837-1847.
2. National Center for Health Statistics, US, 2004 with Chartbook on Trends in the Health of Americans. Hyattsville, Maryland, 2004.
3. Helfand M, Carson S. Screening for lipid disorders in adults: Selective update of 2001 U.S. Preventive Services Task Force review. Prepared for the Agency for Healthcare Research and Quality; by the Oregon Evidence-based Practice Center at the Oregon Health and Science University, Portland, Oregon, under Contract Number 290-02-0024. April 2008. Evidence Synthesis No. 49. AHRQ Publication No. 08-05114-EF-1. Available at http://www.ahrq.gov/downloads/pub/prevent/pdfser/lipides.pdf.
Is screening effective for disease
Screening for and identifying lipid disorders in adults do not appear to have important psychological sequelae or produce important changes in indices of mental health. The research to date has not been sufficient, however, to rule out important changes in small subsets of patients or to detect subtle changes in anxiety.
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Date: June 2008